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Genomic landscape of non-small-cell lung cancer in smokers and never-smokers
  1. Niruthika Sritharan
  1. Correspondence to Dr Niruthika Sritharan, FY2, Department of Medicine, St Mary's Hospital, London, UK, W1 1NY; nsritharan87{at}gmail.com

https://doi.org/10.1136/thoraxjnl-2013-203400

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    Whole-genome and transcriptome sequencing studies were performed on 17 tumour and adjacent normal tissue samples from smokers, former light smokers and never-smokers diagnosed with non-small-cell lung cancer.

    This sequencing-based study revealed a markedly distinct genomic landscape in smokers and never-smokers. Smokers had an average mutation frequency 10-fold higher than never-smokers and a significantly …

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