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Miscellanea
Journal club
Mycobacterium tuberculosis DNA facilitates selective autophagy within infected macrophages
  1. Rawya Ahmed
  1. Correspondence to Rawya Ahmed; rkia{at}doctors.org.uk

https://doi.org/10.1136/thoraxjnl-2012-202844

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    Selective autophagy is a housekeeping energy-generating cytosolic process through which organelles and protein aggregates are tagged within a double-membrane autophagosome and delivered to the lysosome for proteolysis releasing amino acids and generating ATP. The molecular mechanisms underlying protein selection for degradation and ubiquitin complex formation within the cytosol are yet to be elucidated. …

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    Footnotes

      • Watson JO, Manzanillo PS, Cox JS. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell 2012;150:803–15.

    • Competing interests None.

    • Provenance and peer review Not commissioned; internally peer reviewed.