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PostScript
Correspondence
Idiopathic pulmonary fibrosis or not: antibiotic prophylaxis for all patients on immunosuppressants
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Shulgina et al 1 reported the effects of co-trimoxazole on outcomes in fibrotic idiopathic interstitial pneumonia (IIP). We have some concerns about their conclusions and the emphasis of their findings.
With nearly half (43%) of subjects taking ≥10 mg of prednisolone daily, a dose that increases infection risk,2 and over 30% taking a steroid-sparing agent, a valid alternate explanation for their results is that the beneficial effects of co-trimoxazole were due to prevention of adverse effects of immunosuppressive drugs. The occurrence of fewer pneumonias …
Footnotes
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Competing interests None.
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Provenance and peer review Not commissioned; externally peer reviewed.