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Miscellanea
Journal club
Reduced pH in the airways alters bacterial killing in CFTR−/− porcine lungs
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  1. Elspeth Potton
  1. Correspondence to Dr Elspeth Potton, Division of Infection and Immunity, UCL, Cruciform Building, Gower Street, London WC1E 6BT, UK; elspethpotton{at}doctors.org.uk

https://doi.org/10.1136/thoraxjnl-2012-202842

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    Molecular defects in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene are well understood. Despite this, how defects in the CFTR lead to CF is not clear. This paper addresses the mechanism of impaired bacterial killing in a CF model of disease developed in pigs (CFTR−/−), which mirrors human disease.

    Viability of bacteria within the airways …

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