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Intrapleural minocycline for spontaneous PTx?
Current initial treatment for primary spontaneous pneumothorax (PTx) has a substantial rate of recurrence. In this study (Lancet 2013;381:1277–82), investigators randomly assigned patients with a first episode of PTx to receive minocycline pleurodesis or simple aspiration and drainage. At 1 year, 29.2% patients in the minocycline group had a recurrence of PTx, compared with 49.1% of the control group, suggesting minocycline pleurodesis should be standard therapy for PTx.
RV function as a predictor of negative outcome in lung transplant
Right ventricular (RV) dysfunction has a poor prognosis in patients with chronic cardiopulmonary disease. Here, the influence of RV function at rest and during exercise on mortality in patients awaiting lung transplantation was explored (BMJ Open 2013;3:e002108). The inability to increase RV ejection fraction during exercise is a sign of latent dysfunction, and the authors found RV ejection fraction during exercise was an independent predictor of death. This assessment could be useful in aiding prioritisation of …
Footnotes
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Competing interests None.
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Provenance and peer review Commissioned; internally peer reviewed.