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Miscellanea
Journal club
Intergrin α9β1 potentially plays a role in reducing airway smooth muscle contraction
  1. Mark Spears
  1. Correspondence to Dr Mark Spears, University of Glasgow and Respiratory Department, Glasgow Royal Infirmary, G4 OSF, UK; mark.spears{at}glasgow.ac.uk

https://doi.org/10.1136/thoraxjnl-2012-202843

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    Contraction of airway smooth muscle in response to innocuous stimuli is pathognomonic of asthma. However the mechanisms responsible for the loss of normal control are only partially understood. Therefore the authors sought to explore the modulatory role of integrin α9β1 on airway smooth muscle contraction given previous results demonstrating high expression levels in mouse airway smooth …

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    Footnotes

    • Competing interests None.

    • Provenance and peer review Not commissioned; externally peer reviewed.