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We understand the reservations highlighted by Sohal and Walters in their letter in response to our recent work published.1
In their letter, Sohal and Walters argue that E-cadherin and ZO-1 are absent in our immunohistochemistry analysis of small bronchi of smokers and COPD patients, and that if disappeared completely epithelium would fall apart.1 In our study, we detected downregulation of E-cadherin and ZO-1 as well as a change of intercellular and apical distribution to diffuse cytoplasmic redistribution (figure 3B; in our work published in Thorax on 7 January 2013),2 but not …
Footnotes
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Contributors This work was supported by grants SAF2011-26443 (JC), FIS CP11/00293(JM), CIBERES (CB06/06/0027), ADE10/00020 (Spanish government), ACIF/2010/114 (TP) and research grants from Regional Government (Prometeo/2008/045, ‘Generalitat Valenciana’. Support from the CENIT programme (Spanish Government) was obtained.
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Competing interests None.
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Patient consent Obtained.
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Ethics approval The Human Research Ethics Committee of University General Hospital Consortium (Valencia).
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Provenance and peer review Not commissioned; internally peer reviewed.
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