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Correspondence
Authors’ response to: Epithelial mesenchymal transition (EMT) in small airways of COPD patient
  1. Javier Milara1,2,3,
  2. Teresa Peiró3,
  3. Adela Serrano3,
  4. Julio Cortijo1,3,4
  1. 1 Clinical Research Unit (UIC), University General Hospital Consortium, Valencia, Spain
  2. 2 Department of Biotechnology, Universidad Politécnica de Valencia, Valencia, Spain
  3. 3 Research Foundation of General Hospital of Valencia, Valencia, Spain
  4. 4 Department of Pharmacology, University of Valencia, Valencia, Spain
  1. Correspondence to Dr Javier Milara, Clinical Research Unit (UIC), University General Hospital Consortium, Valencia, Spain. Av tres cruces s/n, Valencia E-46014, Spain; xmilara{at}hotmail.com

https://doi.org/10.1136/thoraxjnl-2013-203484

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    We understand the reservations highlighted by Sohal and Walters in their letter in response to our recent work published.1

    In their letter, Sohal and Walters argue that E-cadherin and ZO-1 are absent in our immunohistochemistry analysis of small bronchi of smokers and COPD patients, and that if disappeared completely epithelium would fall apart.1 In our study, we detected downregulation of E-cadherin and ZO-1 as well as a change of intercellular and apical distribution to diffuse cytoplasmic redistribution (figure 3B; in our work published in Thorax on 7 January 2013),2 but not …

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    Footnotes

    • Contributors This work was supported by grants SAF2011-26443 (JC), FIS CP11/00293(JM), CIBERES (CB06/06/0027), ADE10/00020 (Spanish government), ACIF/2010/114 (TP) and research grants from Regional Government (Prometeo/2008/045, ‘Generalitat Valenciana’. Support from the CENIT programme (Spanish Government) was obtained.

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval The Human Research Ethics Committee of University General Hospital Consortium (Valencia).

    • Provenance and peer review Not commissioned; internally peer reviewed.

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