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Correspondence
Epithelial mesenchymal transition (EMT) in small airways of COPD patients
  1. Sukhwinder Singh Sohal,
  2. Eugene Haydn Walters
  1. NHMRC Centre of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, Australia
  1. Correspondence to Professor Eugene Haydn Walters, NHMRC Centre for Research Excellence in Chronic Respiratory Disease and School of Medicine, MS1, 17 Liverpool Street, Private Bag 23, Hobart, Tasmania 7000, Australia; haydn.walters{at}utas.edu.au, sssohal{at}utas.edu.au

https://doi.org/10.1136/thoraxjnl-2013-203373

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    We congratulate Milara et al 1 for getting a paper suggesting that epithelial mesenchymal transition (EMT) is important in the pathogenesis of chronic obstructive pulmonary disease (COPD) into a top respiratory journal. This is quite a breakthrough.

    In the discussion, Milara et al were somewhat dismissive of our findings on EMT markers in large airways of COPD patients;2 commenting that our study was limited by the mesenchymal protein expressions analysed (MMP-9, S100A4, vimentin) being potentially expressed by inflammatory cells. In a follow-up paper3 we excluded such confounding. Further, our study illustrated that cells in the basal epithelium, and reticular basement membrane (Rbm) in smokers/COPD double-stain for cytokeratin-(s) and the ‘EMT marker’ S100A4, confirming a likely epithelial origin …

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