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Audit, research and guideline update
Pleurodesis outcome in malignant pleural mesothelioma
  1. Edward Thomas Hamilton Fysh1,2,
  2. Sze Khen Tan1,3,
  3. Catherine Ann Read1,
  4. Felicity Lee1,
  5. Kate McKenzie1,
  6. Nola Olsen4,
  7. Indunil Weerasena1,
  8. Timothy Threlfall5,
  9. Nicholas de Klerk4,
  10. A William Musk1,4,
  11. Y C Gary Lee1,2
  1. 1Respiratory Department, Sir Charles Gairdner Hospital, Perth, Australia
  2. 2Department of Medicine, School of Medicine and Pharmacology, Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia
  3. 3Department of General Medicine, Khoo Teck Puat Hospital, Singapore, Singapore
  4. 4School of Population Health, University of Western Australia, Perth, Australia
  5. 5Western Australian Cancer Registry, Western Australia Department of Health, Australia
  1. Correspondence to Professor Y C Gary Lee, University Department of Medicine, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia; gary.lee{at}uwa.edu.au

Abstract

Few data exist on the pleurodesis outcome in patients with malignant pleural mesothelioma (MPM). A retrospective review of the Western Australian Mesothelioma Registry over 5 years revealed 390 evaluable patients. Only a subset of patients (42.3%) underwent pleurodesis, surgically (n=78) or by bedside instillation of sclerosants (n=87). Surgical pleurodesis showed no advantages over bedside pleurodesis in efficacy (32% vs 31% failures requiring further drainage, p=0.98), patient survival (p=0.52) or total time spent in hospital from procedure till death (p=0.36). No clinical, biochemical or radiographic parameters tested adequately predict pleurodesis outcome.

  • Mesothelioma
  • Thoracic Surgery
  • Pleural Disease
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