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Oestrogen induces mucoid conversion of Pseudomonas Aeruginosa in women with cystic fibrosis, and increases exacerbations
  1. Gemma Hayes
  1. Correspondence to Dr Gemma Hayes, Department of Respiratory Medicine, Derriford Hospital, Derriford Road, ST4, Crownhill, Plymouth PL6 8DH, UK; gemmahayes1{at}

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This study assesses whether oestradiol contributes to early mucoid pseudomonas colonisation and increased exacerbation frequency in female patients with cystic fibrosis (CF).

In vitro oestradiol induced more alginate production, defining mucoid conversion, at 3 days and 4 weeks compared with ethanol and testosterone, and more mucoid colonies were seen at 4 weeks following oestradiol culture. In …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.