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Footnotes
All authors had full access to all the data in the study, and take full responsibility for the integrity of the data and the accuracy of the data analysis.
Contributors SB, MD and IS designed the study and obtained ethical approval. LS completed the statistical analysis and generated the figures. SB, MD and IS co-wrote the manuscript. All authors approved the final version.
Funding The research project was funded by a project grant from the Research & Development Department, Papworth Hospital NHS Trust. LS was supported by the Medical Research Council (Unit Programme number U015232027).
Competing interests None.
Patient Consent Obtained.
Ethics approval The study was conducted with approval of the Cambridgeshire III Research Ethics Committee (REC ref. no: 10/H0306/9).
Provenance and peer review Not commissioned; externally peer reviewed.