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Original article
Longitudinal association between lung function and health-related quality of life in cystic fibrosis
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  1. Janice Abbott1,
  2. Margaret A Hurley2,
  3. Alison M Morton3,
  4. Steven P Conway3
  1. 1School of Psychology, University of Central Lancashire, Preston, UK
  2. 2School of Health, University of Central Lancashire, Preston, UK
  3. 3Adult Cystic Fibrosis Unit, St James’ Hospital, Leeds, UK
  1. Correspondence to Professor Janice Abbott, School of Psychology, University of Central Lancashire, Darwin Building, Preston PR1 2HE, UK; jabbott{at}uclan.ac.uk

Abstract

Background Lung function is an important indicator of cystic fibrosis disease status and those with better forced expiratory volume in 1 s (FEV1)% predicted have tended to report a better health-related quality of life (HRQoL) in cross-sectional studies. The relationship between lung function and HRQoL over time is unknown. This work assesses the natural progression of HRQoL reporting over many years and compares assessments across a whole decade and evaluates the relationship between lung function and HRQoL longitudinally.

Methods Demographic (age, gender), clinical (FEV1% predicted, body mass index, diabetes, Burkholderia cepacia complex, intravenous access device and nutritional status) and HRQoL (Cystic Fibrosis Quality of Life Questionnaire) variables were obtained every 2 years over a 12-year period (seven time points from 1998 to 2010).

Results HRQoL and lung function declined slowly over time and significant decade changes were observed for FEV1% predicted and the nine domains of the Cystic Fibrosis Quality of Life Questionnaire. The results of random coefficient modelling indicated that, at the population level, decreasing FEV1% predicted was associated with decreasing HRQoL after adjusting for confounding variables. However, the percentage of patients for whom a decrease in lung function was associated with a decrease in HRQoL differed according to the quality of life domain.

Conclusions HRQoL and FEV1% predicted decline slowly; nevertheless, a decrease in lung function predicted a decrease in HRQoL over time.

  • Cystic Fibrosis
  • Psychology
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