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Correspondence
What is top of the charts? BPIFB1/LPLUNC1 localises to the bronchiolised epithelium in the honeycomb cysts in UIP
  1. Colin D Bingle1,
  2. Bianca Araujo1,
  3. William A Wallace2,
  4. Nik Hirani3,
  5. Lynne Bingle4
  1. 1Department of Infection and Immunity, University of Sheffield, Sheffield, UK
  2. 2Department of Pathology, University of Edinburgh, Edinburgh, UK
  3. 3MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
  4. 4School of Clinical Dentistry, University of Sheffield, Sheffield, UK
  1. Correspondence to Dr Colin Bingle, Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield S10 2JF, UK; c.d.bingle{at}sheffield.ac.uk

https://doi.org/10.1136/thoraxjnl-2013-204179

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    Transcriptomic analyses are increasingly being used to define the molecular phenotype of complex diseases and may yet allow the identification of novel diagnostic and prognostic markers. Yang et al1 are to be congratulated for their meticulous application of this technology to the systematic study of gene signatures from patients with Idiopathic Pulmonary Fibrosis (IPF). This study, which appears to be the largest data set yet published, identifies two distinct gene signatures with high expression of ‘cilium-associated genes’ being shown to be associated with cases that exhibit microscopic honeycombing, which is commonly observed in, but not specific to, ‘Usual Interstitial Pneumonia’ (UIP), the pathological pattern of remodelling seen in IPF. This metaplastic bronchial type epithelium within the honeycomb spaces has recently been the …

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    Footnotes

    • Contributors CDB and LB conceived the study. BA and LB undertook the IHC work. CDB, BA and LB took the images. NH and WAW were responsible for patient identification, diagnosis and provided the samples. WAW provided pathological input.

    • Funding European Respiratory Society (grant number MC1562-2010).

    • Competing interests BA was supported by an ERS Long Term Research Fellowship.

    • Ethics approval South Sheffield Research Ethics Committee.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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