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November Journal club summaries
  1. Simon Rolin
  1. Correspondence to Simon Rolin, ST7 Respiratory and General Internal Medicine, Heart and Lung Unit, South Devon Healthcare NHS Foundation Trust, Torbay Hospital, Newton Road, Torquay, Devon TQ2 7AA, UK

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Diabetes and OSA in pregnancy

In this observational case control study, polysomnography was used to objectively assess the relationship between pregnancy, obstructive sleep apnoea (OSA) and gestational diabetes mellitus (JCEM Published Online First: 21 August 2013. doi10.1210/jc.2013-2348). Comparison was made between matched groups of non pregnant nondiabetic women, pregnant women with normal glucose tolerance, and pregnant women with gestational diabetes. Pregnant women were studied during the late second trimester to early third trimester. Pregnancy alone was associated with sleep disturbance. OSA was found to be more prevalent in pregnant women with gestational diabetes than in pregnant women with normal glucose tolerance (73% vs 27%, p=0.05). After adjustment for pre-pregnancy body mass index, the diagnosis of gestational diabetes was associated with a diagnosis of OSA (OR 6.60 (1.15–37.96)).

Apixaban for VTE

Apixaban is an oral factor Xa inhibitor with a rapid onset of action and predictable pharmacokinetics that allow a fixed-dose regimen. These characteristics may simplify the treatment of venous thromboembolism, without the need for blood …

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