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Audit update
The relationship between clinical outcomes and medication adherence in difficult-to-control asthma

Abstract

Medication non-adherence and the clinical implications in difficult-to-control asthma were audited. Prescription issue data from 115 patients identified sub-optimal adherence (<80%) in 65% of patients on inhaled corticosteroids (ICS) or combined ICS/long-acting β2 agonist (LABA). In those using separate ICS and LABA, adherence to LABA (50%) was significantly better than to ICS (14.3%). Patients with sub-optimal ICS adherence had reduced FEV1 and higher sputum eosinophil counts. Adherence ratio was an independent predictor of previous ventilation for acute severe asthma (p=0.008). The majority of patients with difficult-to-control asthma are non-adherent with their asthma medication. Non-adherence is correlated with poor clinical outcomes.

  • Asthma
  • anti-asthmatic drugs
  • adherence
  • medication
  • compliance
  • allergic lung disease
  • asthma pharmacology
  • COPD mechanisms
  • asthma mechanisms
  • COPD exacerbations
  • cough/mechanisms/pharmacology
  • airway epithelium
  • cytokine biology
  • eosinophil biology
  • innate immunity
  • asthma guidelines
  • clinical epidemiology
  • exhaled airway markers

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