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Miscellanea
Journal club
Endothelial cells as regulators of cytokine storms during influenza infection
  1. M Gautam
  1. Correspondence to Dr M Gautam, ST6 Respiratory Medicine, University Hospital of Aintree, Liverpool, UK; manish16gautam{at}gmail.com

https://doi.org/10.1136/thoraxjnl-2011-201437

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    The morbidity and mortality of severe influenza infections has been attributed to excessive inflammatory cytokine production and early innate immune cell recruitment. This study highlights the pulmonary endothelium as a central regulator of the cytokine storm, in particular demonstrating the role of the sphingosine-1-phosphate (S1P1) signalling system.

    S1P1 receptor specific agonists were shown to significantly reduce …

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    Footnotes

    • Provenance and peer review Not commissioned; internally peer reviewed.