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Miscellanea
Journal club
Mechanisms underlying the increase in mycobacterial infections in cystic fibrosis patients on azithromycin
  1. Gareth Jones
  1. Correspondence to Dr Gareth Jones, ST5, Amanda Unit, Liverpool Heart & Chest Hospital, Thomas Drive, Liverpool L14 3PE, UK; garethhuw{at}doctors.org.uk

https://doi.org/10.1136/thoraxjnl-2011-201327

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    This study investigated the increased incidence of non-tuberculous mycobacterium (NTM) infections in cystic fibrosis (CF) patients on azithromycin. The authors were particularly interested in autophagia, a process whereby intracellular material is isolated into phagosomes and then destroyed by being fused with acid-rich lysosomes. It is disrupted by other macrolides and is crucial for the clearance of intracellular …

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    • Provenance and peer review Not commissioned; internally peer reviewed.