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Revisiting intrapleural fibrinolysis in empyema
  1. Andrew Fester
  1. Correspondence toAndrew Thomas Fester, University College London, Kamsahd, The Avenue, Sleights, Whitby, North Yorkshire YO22 5BS, UK; a.fester{at}

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In this double-blind, double-dummy, factorial trial performed across 11 centres in the UK, tissue plasminogen activator (t-PA) was used in combination with DNase in the treatment of pleural infection and compared with double placebo. Each treatment individually was also compared with the placebo group.

The primary end point measured the percentage change in area of …

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