Article Text
PDFChest clinic
Basic science for the chest physician
Genome-wide association studies in lung disease
Abstract
Genome-wide association studies (GWAS) have provided new insights into the molecular mechanisms of lung function and lung diseases. GWAS, and studies that build upon their findings, will continue to provide evidence aimed at advancing understanding of lung disease. This paper summarises the key features of a GWAS, references some recent findings and discusses how the chest physician can interpret the validity and utility of future GWAS and related studies.
- Asthma genetics
- respiratory measurement
- COPD epidemiology
- clinical epidemiology
- COPD mechanisms
- asthma
- asthma mechanisms
- COPD exacerbations
- cough/mechanisms/pharmacology
- asthma guidelines
- cystic fibrosis
- exhaled airway markers
- lung physiology
- paediatric asthma
- paediatric lung disaese
- airway epithelium
- allergic lung disease
- cytokine biology
- eosinophil biology
- innate immunity
- lymphocyte biology
- airway epithelium
- allergic lung disease
- eosinophil biology
- asthma genetics
- respiratory measurement