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  1. Nicolas Regamey1,2,3,
  2. Peter K Jeffery2,
  3. Eric W F W Alton2,
  4. Andrew Bush1,
  5. Jane C Davies1,2
  1. 1Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
  2. 2Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK
  3. 3Department of Paediatrics, University Hospital of Bern, Bern, Switzerland
  1. Correspondence to Nicolas Regamey M.D., Division of Paediatric Respiratory Medicine, University Children's Hospital, 3010 Bern, Switzerland; nicolas.regamey{at}

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We thank Burgel and colleagues for their valuable comments.1 We agree that a cautious approach should be adopted when considering the use of bronchoscopy and biopsy in cystic fibrosis (CF) research. As stated in our review article,2 we have confirmed the safety of endobronchial biopsy in children and infants with CF. Reassuringly, we have encountered no complications even in children with advanced lung disease. We advocate the use of endobronchial biopsy to investigate mechanisms of airway remodelling events and their relationship to infection and inflammation in children, but claim no experience of bronchoscopy in adult CF. It would be inappropriate for us to comment on the role of bronchoscopy in adults.


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  • Linked article 200824.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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