• Bronchial biopsy
• airway remodelling
• airway inflammation
• epithelium
• cystic fibrosis
• airway epithelium
• COPD epidemiology
• COPD exacerbations
• bronchiectasis
• respiratory measurement
• histology/cytology

We read with interest the article by Regamey et al who reviewed the relationship of airway remodelling to inflammation in cystic fibrosis (CF).1 The authors suggested that endobronchial biopsy studies are useful for studying airway remodelling in CF. Four studies were conducted in 91 children who underwent bronchoscopy for clinical reasons or annual routine surveillance. These studies confirmed that airway remodelling in CF appeared early in life and this is indeed of more than academic interest. However, while the authors have previously shown …