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Therapeutic advances in non-small cell lung cancer
  1. Eric Vallières1,
  2. Solange Peters2,
  3. Paul Van Houtte3,
  4. Paras Dalal4,
  5. Eric Lim5
  1. 1Department of Thoracic Surgery, Swedish Cancer Institute, Seattle, Washington, USA
  2. 2Department of Medical Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  3. 3Department of Radiation Oncology, Institute Bordet, Université Libre de Bruxelles, Brussels, Belgium
  4. 4Department of Radiology, Harefield Hospital, London, UK
  5. 5Imperial College and Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, UK
  1. Correspondence to Eric Lim, Academic Division of Thoracic Surgery, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK; e.lim{at}


Despite decades of research, therapeutic advances in non-small cell lung cancer (NSCLC) have progressed at a painstaking slow rate with few improvements in standard surgical resection for early stage disease and chemotherapy or radiotherapy for patients with advanced disease. In the past 18 months, however, we seemed to have reached an inflexion point: therapeutic advances that are centred on improvements in the understanding of patient selection, surgery that is undertaken through smaller incisions, identification of candidate mutations accompanied by the development of targeted anticancer treatments with a focus on personalised medicine, improvements to radiotherapy technology, emergence of radiofrequency ablation (RFA), and last but by no means least, the recognition of palliative care as a therapeutic modality in its own right. The contributors to this review are a distinguished international panel of experts who highlight recent advances in each of the major disciplines.

  • Mesothelioma
  • non-small cell lung cancer
  • small cell lung cancer
  • thoracic surgery
  • tobacco and the lung
  • lung volume reduction surgery
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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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