You are here

Article Text

Article menu
Download PDFPDF
Miscellaneous
Journal club
Histamine-releasing factor: a possible future therapeutic target for asthma and allergy
  1. Victoria Elizabeth Beasley
  1. Correspondence to Dr Victoria Elizabeth Beasley, ST2. Imperial NHS Trust, Department of Renal Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK; vebeasley{at}doctors.org.uk

https://doi.org/10.1136/thoraxjnl-2012-201726

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Mast cells and basophils are key players in the IgE-dependent allergic response. These cells trigger an inflammatory cascade by secreting numerous preformed pro-inflammatory chemical mediators such as histamine, proteases and cytokines into the blood. Histamine-releasing factor (HRF), found in nasal, skin blister and bronchoalveolar lavage fluids, is a protein secreted by macrophages that can stimulate histamine, …

    View Full Text

    Footnotes

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.