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Linking mechanisms to prognosis in pulmonary arterial hypertension
S70 Diagnostic utility and prognostic value of quantitative cardiac MR indices in patients with suspected pulmonary hypertension
  1. A J Swift1,
  2. S Rajaram1,
  3. R Condliffe2,
  4. D Capener1,
  5. C Hill3,
  6. C Davies3,
  7. J Hurdman2,
  8. C Elliot2,
  9. J M Wild1,
  10. D G Kiely2
  1. 1University of Sheffield, Sheffield, UK
  2. 2Sheffield Pulmonary Vascular Disease Unit, Sheffield, UK
  3. 3Radiology Department, Hull and East Yorkshire Hospitals NHS Trust, Sheffield, UK


Introduction and Objectives The aim of this study was to assess the clinical utility of quantitative MR indices of cardiac morphology and function in a large cohort of patients with pulmonary hypertension (PH).

Methods We retrospectively studied 233 consecutive patients with suspected PH who underwent cardiac MRI and right heart catheterisation (RHC) within 48 h. Four chamber and short axis (SA) CINE images were acquired using cardiac gated multi-slice imaging with a steady state free precession sequence at 1.5T. The diagnostic and prognostic significance of quantitative measurements of right ventricular morphology and function were assessed.

Results Right ventricular end-diastolic mass index was the measurement with the strongest correlation with mPAP (r=0.74) and the highest diagnostic accuracy for the detection of PH (area under the receiver operator curve of 0.91). During the mean follow-up of 18 months (0–36 months), 36 patients with PH died. Right ventricular ejection fraction (p=0.003), right ventricular stroke volume index (p=0.03) and IVC size (p=0.01) were the MR predictors of mortality across the subgroups of PH. MR measurements of right ventricular ejection fraction (p=0.004), right ventricular stroke volume index (p=0.02), and left ventricular diastolic eccentricity index (p=0.005), all predicted mortality in patients with pulmonary arterial hypertension, Abstract S70 figure 1 below shows the Kaplan–Meier plots the MR predictors of mortality in PAH. IVC size (p=0.018) was an independent predictor of mortality in the full cohort of patients with PH, and diastolic eccentricity index (p=0.037) was an independent predictor of adverse outcome in patients with PAH.

Abstract S70 Figure 1

Kaplan–Meier plots showing the survival curves for patients with PAH above and below the median value of MR derived right ventricular stroke volume index (RVSVI), right ventricular ejection fraction (RVEF) and diastolic eccentricity index (dEI).

Conclusion Cardiac MRI provides a comprehensive assessment of right ventricular morphology and function in patients with PH. This study confirms the diagnostic and prognostic applicability of MRI in unselected patients with PH of varied aetiologies in a practical clinical setting.

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