Article Text


NIV: COPD, neuromuscular disease and obesity
P269 Feasibility and acceptability of non-invasive ventilation (NIV) as an aid to exercise in patients admitted with acute exacerbation of chronic respiratory disease
  1. F Dyer,
  2. F Bazari,
  3. C Jolley,
  4. L Flude,
  5. V Lord,
  6. M I Polkey,
  7. N S Hopkinson
  1. NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK


Introduction Patients with acute exacerbations of chronic respiratory disease are often too breathless to exercise, leading to muscle deconditioning. Using NIV to assist exercise during an exacerbation might prevent this, but it is not known if this is acceptable to patients.

Methods 12 in-patients with an acute exacerbation (including Bronchiectasis and CF) were recruited. If they were unable to cycle for 5 min at 20 Watts unassisted they then cycled with NIV for up to 20 min. NIV settings were adjusted to patient comfort. Patients were asked to rate their level of distress and willingness to repeat the intervention.

Results Mean age was 50.6 (21.3). 44% male. 53% used NIV at night. All were naïve to NIV during exercise. NIV increased cycle time by 146 s (105%). All stated they would be prepared to repeat this type of exercise (Abstract P269 table 1).

Abstract P269 Table 1

Times cycled and change in parameters with exercise

Conclusion NIV is well tolerated, feasible and significantly increases exercise capacity in patients hospitalised with an acute exacerbation of respiratory disease.

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