The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

Richard I Carter; Richard A Mumford; Kelly M Treonze; Paul E Finke; Phillip Davies; Qian Si; John L Humes; Asger Dirksen; Eeva Piitulainen; Ali Ahmad; Robert A Stockley

doi:10.1136/thx.2010.154690

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Chronic obstructive pulmonary disease

Original article

The fibrinogen cleavage product Aα-Val³⁶⁰, a specific marker of neutrophil elastase activity in vivo

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	Abstract	Full	Pdf
May 2011	57	10	22
Jun 2011	97	29	31
Jul 2011	455	38	66
Aug 2011	115	29	68
Sep 2011	35	14	50
Oct 2011	42	21	22
Nov 2011	50	12	12
Dec 2011	36	13	11
Jan 2012	59	11	6
Feb 2012	63	20	14
Mar 2012	62	13	7
Apr 2012	62	7	7
May 2012	46	12	9
Jun 2012	61	5	5
Jul 2012	55	8	15
Aug 2012	39	16	15
Sep 2012	35	17	12
Oct 2012	40	3	4
Nov 2012	34	20	12
Dec 2012	32	14	7
Jan 2013	43	10	15
Feb 2013	38	7	6
Mar 2013	55	11	15
Apr 2013	33	10	5
May 2013	43	8	4
Jun 2013	23	8	14
Jul 2013	31	6	7
Aug 2013	36	8	11
Sep 2013	37	5	6
Oct 2013	31	10	14
Nov 2013	15	6	9
Dec 2013	17	3	6
Jan 2014	22	3	4
Feb 2014	40	5	6
Mar 2014	28	6	8
Apr 2014	37	5	12
May 2014	31	10	5
Jun 2014	19	18	4
Jul 2014	36	11	8
Aug 2014	13	14	8
Sep 2014	20	12	12
Oct 2014	21	15	21
Nov 2014	10	16	11
Dec 2014	10	5	7
Jan 2015	12	15	12
Feb 2015	27	14	19
Mar 2015	16	15	19
Apr 2015	16	15	14
May 2015	15	8	11
Jun 2015	5	9	15
Jul 2015	10	15	19
Aug 2015	23	23	10
Sep 2015	28	11	11
Oct 2015	14	6	10
Nov 2015	11	6	17
Dec 2015	10	12	13
Jan 2016	12	9	19
Feb 2016	9	10	18
Mar 2016	8	15	27
Apr 2016	13	11	16
May 2016	17	13	24
Jun 2016	26	21	43
Jul 2016	11	12	37
Aug 2016	22	4	24
Sep 2016	32	12	27
Oct 2016	34	22	26
Nov 2016	15	7	18
Dec 2016	17	11	18
Jan 2017	13	15	6
Feb 2017	4	9	17
Mar 2017	0	11	8
Apr 2017	1	17	6
May 2017	1	16	8
Jun 2017	9	22	25
Jul 2017	33	33	24
Aug 2017	18	18	9
Sep 2017	34	34	20
Oct 2017	32	26	10
Nov 2017	30	28	18
Dec 2017	46	36	14
Jan 2018	28	26	18
Feb 2018	45	33	20
Mar 2018	47	39	29
Apr 2018	42	40	18
May 2018	32	28	11
Jun 2018	32	20	18
Jul 2018	26	22	18
Aug 2018	18	18	14
Sep 2018	36	34	29
Oct 2018	26	20	17
Nov 2018	20	18	22
Dec 2018	19	19	12
Jan 2019	23	21	18
Feb 2019	26	23	22
Mar 2019	22	20	26
Apr 2019	22	19	19
May 2019	18	18	20
Jun 2019	23	23	26
Jul 2019	26	26	23
Aug 2019	24	22	14
Sep 2019	30	28	21
Oct 2019	41	38	17
Nov 2019	27	28	22
Dec 2019	23	19	17
Jan 2020	20	18	17
Feb 2020	37	37	26
Mar 2020	41	37	22
Apr 2020	15	15	15
May 2020	19	19	12
Jun 2020	35	35	15
Jul 2020	34	31	18
Aug 2020	6	6	23
Sep 2020	37	37	31
Oct 2020	79	69	43
Nov 2020	31	31	36
Dec 2020	28	23	14
Jan 2021	21	14	21
Feb 2021	15	15	32
Mar 2021	31	29	14
Apr 2021	31	25	18
May 2021	18	16	21
Jun 2021	17	17	22
Jul 2021	12	12	22
Aug 2021	16	17	23
Sep 2021	24	24	24
Oct 2021	18	16	37
Nov 2021	17	13	38
Dec 2021	23	21	14
Jan 2022	23	23	22
Feb 2022	55	41	21
Mar 2022	52	45	35
Apr 2022	42	37	17
May 2022	79	77	68
Jun 2022	54	53	31
Jul 2022	35	28	14
Aug 2022	57	57	21
Sep 2022	50	52	35
Oct 2022	56	50	21
Nov 2022	31	29	23
Dec 2022	29	27	16
Jan 2023	43	42	26
Feb 2023	33	31	8
Mar 2023	50	47	10
Apr 2023	45	40	34
May 2023	35	32	36
Jun 2023	37	39	17
Jul 2023	29	29	29
Aug 2023	47	42	33
Sep 2023	33	28	37
Oct 2023	34	37	33
Nov 2023	27	27	15
Dec 2023	49	47	12
Jan 2024	93	45	16
Feb 2024	50	50	31
Mar 2024	32	28	82
Apr 2024	26	25	20
May 2024	135	100	17
Jun 2024	106	5	4
Jul 2024	123	14	4
Aug 2024	114	12	1
Total	5793	3503	3063

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