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Inactivation of the N-terminal of ACE reduces bleomycin-induced lung fibrosis
  1. S Haque
  1. Correspondence to S Haque, Foundation Year 2 Doctor, King George Hospital, Essex, IG3 8YB, UK; shariahhaque{at}

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This study examined bleomycin-induced lung injury in normotensive mice, termed N-KO and C-KO, which have point mutations inactivating the N- or C-terminal catalytic sites of angiotensin converting enzyme (ACE), respectively. N-KO, but not C-KO mice, exhibited a marked resistance to bleomycin-induced lung injury and fibrosis, as …

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