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Human neutrophil chemotaxis regulation by α-1 antitrypsin
  1. L H White
  1. Correspondence to L H White, Respiratory Department, Great Western Hospital, Swindon, UK; laura.white{at}gwh.nhs.uk

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α-1 Antitrypsin (AAT) has anti-inflammatory roles beyond regulation of proteases. Chronic lung disease in α-1 antitrypsin deficiency (AATD) is characterised by neutrophilic inflammation. This series of experiments investigated the effects of AAT on neutrophil chemotaxis by comparing neutrophils from patients with AATD with controls, both in vitro and in vivo.

Chemotaxis to both IL-8 and soluble …

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