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  1. Yvette R B M van Gestel,
  2. Don Poldermans
  1. Department of Anaesthesiology, Erasmus Medical Centre, Rotterdam, The Netherlands
  1. Correspondence to Don Poldermans, Erasmus Medical Centre Rotterdam, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; d.poldermans{at}

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We thank Drs Young and Hopkins for their interest in our study1 and their interesting explanation for the results observed. It is indeed likely that the relationship between chronic obstructive pulmonary disease (COPD) and cancer (both pulmonary and extrapulmonary) is attributed to cytokine-induced inflammation mediated by guanosine triphosphatase (GTPase) signalling molecules. This is advocated by the results of Man et …

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