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Lung alert
Tobacco-specific carcinogen NNK has an important role in lung cancer
  1. Leanne Burke
  1. Correspondence to Leanne Burke, York Hospitals NHS Foundation Trust, York, UK; leanneburke{at}

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Lung cancer is the leading cause of mortality in industrialised countries and 85–90% of lung cancers are caused by cigarette smoking. DNA methyltransferase 1 (DNMT1), an enzyme that catalyses DNA methylation, is reported to be overexpressed in patients with lung and liver cancer who are smokers. The …

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