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Lung cancer
Original article
UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer
  1. D R Baldwin1,
  2. S W Duffy2,
  3. N J Wald3,
  4. R Page4,
  5. D M Hansell5,
  6. J K Field6
  1. 1Respiratory Medicine Unit, David Evans Research Centre, Nottingham University Hospitals, City Campus, Nottingham, UK
  2. 2Centre for Epidemiology, Wolfson Institute of Preventative Medicine, London, UK
  3. 3Centre for Environmental and Preventive Medicine in the Wolfson Institute of Preventive Medicine, Barts's and the London School of Medicine, London, UK
  4. 4Liverpool Heart & Chest Hospital, Broadgreen, Liverpool
  5. 5Department of Radiology, Royal Brompton Hospital, London, UK
  6. 6Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Liverpool, UK
  1. Correspondence to Dr David R Baldwin, Respiratory Medicine Unit, David Evans Research Centre, Nottingham University Hospitals, City Campus, Hucknall Road, Nottingham NG5 1PB, UK; david.baldwin{at}nuh.nhs.uk or Dr John K Field, Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Liverpool L3 9TA, UK; j.k.field{at}liv.ac.uk

Abstract

The UK Lung Screen (UKLS) is a randomised controlled trial of the use of low-dose multidetector CT for lung cancer screening. It completed the Health Technology Appraisal (HTA)-funded feasibility stage in October 2009 and the pilot UKLS will be initiated in early 2011. The pilot will randomise 4000 subjects to either low-dose CT screening or no screening. The full study, due to start in September 2012, if progression criteria are met, will randomise a further 28 000 subjects from seven centres in the UK. Subjects will be selected if they have sufficient risk of developing lung cancer according to the Liverpool Lung Project risk model. The UKLS employs the ‘Wald Single Screen Design’, which was modelled in the UKLS feasibility study. This paper describes the modelling of nodule management in UKLS by using volumetric analysis with a single initial screen design and follow-up period of 10 years. This modelling has resulted in the development and adoption of the UKLS care pathway, which will be implemented in the planned CT screening trial in the UK.

  • Health Economist
  • imaging/CT MRI etc
  • lung cancer

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

https://doi.org/10.1136/thx.2010.152066

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    Footnotes

    • Funding The HTA funded the feasibility study.

    • Competing interests None.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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