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Letter
Indices of bronchial reactivity and sensitivity
  1. Cheryl M Salome,
  2. Nathan J Brown,
  3. Helen K Reddel,
  4. Wei Xuan,
  5. Guy B Marks
  1. Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
  1. Correspondence to Cheryl Salome, Woolcock Institute of Medical Research, PO Box M77, Missenden Rd 2050, NSW Australia; cms{at}woolcock.org.au

https://doi.org/10.1136/thx.2010.151639

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    Cisneros et al1 report associations between scores on the Asthma Quality of Life Questionnaire (AQLQ) and three indices of bronchial reactivity (dose–response slope (DRS), continuous index of responsiveness (CIR) and bronchial reactivity index (BRI)), which they suggest are qualitatively different from sensitivity, measured by PD20FEV1. This conclusion is questionable.

    First, there are no meaningful differences between DRS, CIR and BRI. All are calculated using the final percentage fall in the forced expiratory volume in 1 s (FEV1) and final cumulative dose. The only difference between them is the mathematical transformation applied to the data. Any differences in …

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    Footnotes

    • Linked articles 152470.

    • Competing interests None.

    • Ethics approval This study was conducted with the approval of the Central Sydney Area Health Service Ethics Review Committee.

    • Provenance and peer review Not commissioned; not externally peer reviewed.

    Linked Articles

    • PostScript
      Authors' response
      Carolina Cisneros Francisco García-Río Julio Ancochea
      Thorax 2010; 66 266-266 Published Online First: 27 Oct 2010. doi: 10.1136/thx.2010.152470