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Influenza A/H1N1 in patients with cystic fibrosis in Italy: a multicentre cohort study
  1. Carla Colombo1,
  2. Pier Maria Battezzati2,
  3. Vincenzina Lucidi3,
  4. Giuseppe Magazzù4,
  5. Valentina Motta1,
  6. Gianfranco Alicandro1,
  7. Giovanni Taccetti5,
  8. Teresa Repetto5
  1. 1Departement of Paediatrics, CF Centres of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
  2. 2Dipartimento di Medicina, Chirurgia e Odontoiatria, School of Medicine Ospedale San Paolo, University of Milan, Milan, Italy
  3. 3Unit of Cystic Fibrosis, Department of Paediatric Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy
  4. 4CF and Paediatric Gastroenterology Unit, University of Messina, Messina, Italy
  5. 5Cystic Fibrosis Center, Meyer Hospital, Florence, Italy
  1. Correspondence to Professor Carla Colombo, Cystic Fibrosis Center, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Via Commenda 9, 20122 Milan, Italy; carla.colombo{at}

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The clinical consequences of influenza are severe in cystic fibrosis (CF), but the impact of A/H1N1 virus infection remains poorly defined.1 2 Pandemic influenza A/H1N1 started in Italy in September 2009 and CF patients were included among those at risk of complications and recommended to receive A/H1N1 vaccine. Better characterisation of the impact of influenza A/H1N1 in comparison with other flu-like illnesses in CF would provide a rational basis for antiviral treatment and vaccination strategies for the next flu season.

Within the Italian Cystic Fibrosis Society, we sent a questionnaire to 30 centres to collect follow-up data for all patients with influenza-like symptoms consecutively seen between November 2009 and March 2010. Realtime RTPCR test was performed to define A/H1N1 status.3 Continuous variables are reported as medians, IQR (see online supplement for details of study methods).

Nineteen centres reported data from 127 patients: 68 were ‘A/H1N1+ve’ and 59 were ‘A/H1N1–ve’ for the RT-PCR test.

Symptom onset …

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  • Other members of the Italian Cystic Fibrosis Society (SIFC) Study Group for H1N1: F Alghisi, Unit of Cystic Fibrosis, Department of Paediatric Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome; B M Assael, Cystic Fibrosis Center, Verona; E Bignamini, Pneumology Unit, Regina Margherita Paediatric Hospital, Turin; M Collura, Cystic Fibrosis Center, Di Cristina Hospital, Palermo; S Cristadoro, CF and Paediatric Gastroenterology Unit, University of Messina, Messina; R Gagliardini, Regional Cystic Fibrosis Center, Department of Paediatrics, Ospedali Riuniti, Ancona; A Manca, Cystic Fibrosis Center, University of Bari, Bari; S Notarnicola, Cystic Fibrosis Center, Paediatric Clinics University of Genova, G. Gaslini Children Hospital, Genova; A Negri, Department of Paediatrics, Ospedale di Livorno, Livorno; R Padoan, Cystic Fibrosis Service, AO Spedali Civili, Brescia; G Pizzamiglio, Respiratory Medicine and Cystic Fibrosis Adult Section, Dipartimento Toraco-Polmonare e Cardiocircolatorio, Università degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milano; F Poli, Cystic Fibrosis Center, Ospedale Infantile Burlo Garofolo, Trieste; S Quattrucci, Cystic Fibrosis Regional Center, Sapienza University of Rome, Rome; L Ratclif, U.O.S. Cystic Fibrosis, Cerignola; D Salvatore, Cystic Fibrosis Center, Paediatric Division, San Carlo Hospital, Potenza; V Terlizzi, Department of Paediatrics University of Naples Federico II, Naples.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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