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Miscellanea
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Sildenafil does not improve 6 min walk distance in advanced idiopathic pulmonary fibrosis
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  1. M Lavender
  1. Correspondence to M Lavender, Specialist Registrar, Salisbury District Hospital, Salisbury SP2 8BJ, UK; melanie.lavender{at}salisbury.nhs.uk

http://dx.doi.org/10.1136/thx.2010.145664

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    It has been postulated that sildenafil, a phosphodiesterase-5 inhibitor and pulmonary artery vasodilator, may improve gas exchange in advanced idiopathic pulmonary fibrosis by preferentially increasing perfusion to well-ventilated areas of lung. This double-blind randomised placebo controlled study was designed to investigate the effect of sildenafil on 6 min walk distance (6MWD) in patients with advanced idiopathic …

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