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It has been postulated that sildenafil, a phosphodiesterase-5 inhibitor and pulmonary artery vasodilator, may improve gas exchange in advanced idiopathic pulmonary fibrosis by preferentially increasing perfusion to well-ventilated areas of lung. This double-blind randomised placebo controlled study was designed to investigate the effect of sildenafil on 6 min walk distance (6MWD) in patients with advanced idiopathic …