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Association between the IL6-174G/C SNP and maximally attained lung function
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  1. B van den Borst1,2,
  2. N Y Souren1,3,4,
  3. M Gielen1,3,4,
  4. R J F Loos5,6,
  5. A D C Paulussen1,7,
  6. C Derom8,
  7. A M W J Schols1,2,
  8. M P A Zeegers1,3,4
  1. 1NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands
  2. 2Department of Respiratory Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands
  3. 3Department of Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht University Medical Center+, Maastricht, The Netherlands
  4. 4Unit of Genetic Epidemiology, Department of Public Health and Epidemiology, University of Birmingham, Birmingham, UK
  5. 5Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
  6. 6Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
  7. 7Department of Clinical Genetics, Cluster of Genetics and Cell Biology, Maastricht University Medical Center+, Maastricht, The Netherlands
  8. 8Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
  1. Correspondence to B van den Borst, NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center+, PO Box 616, Maastricht 6200 MD, The Netherlands; b.vdborst{at}pul.unimaas.nl

https://doi.org/10.1136/thx.2009.128108

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    Recently, He et al1 reported that the C allele of the interleukin 6 (IL6)-174G/C promoter polymorphism was associated with a rapid decline in forced expiratory volume in 1 s (FEV1) (≥3% predicted/year) and susceptibility to chronic obstructive pulmonary disease (COPD) in middle-aged smokers derived from three different cohorts.1 Alternatively, as also suggested by He et al in their discussion,1 we hypothesised that the IL6-174G/C single nucleotide polymorphism (SNP) might not only affect the rate of lung function decline but also …

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      Jian-Qing He Loubna Akhabir Don D Sin S F Paul Man Peter D Paré Andrew J Sandford Marilyn G Foreman Dawn L DeMeo Edwin K Silverman
      Thorax 2010; 66 179-180 Published Online First: 26 Oct 2010. doi: 10.1136/thx.2010.149658