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Lactate clearance is not inferior to central venous oxygen saturation as a goal in early sepsis resuscitation
  1. Amelia Dunscombe
  1. Correspondence to Amelia Dunscombe, Bristol Royal Infirmary, Bristol BS2 8HW, UK; ameliadunscombe{at}yahoo.co.uk

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Goal-directed therapy in severe sepsis improves outcome by providing protocol-driven targets for initial resuscitation. Current guidelines use central venous oxygen saturations (Scvo2) to assess oxygen delivery and metabolism, but this requires specialist equipment and expertise which may limit its use. This study addresses whether a change in serum lactate concentration …

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