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- Asthma guidelines
- cystic fibrosis
- exhaled airway markers
- lung physiology
- paediatric asthma
- paediatric lung disaese
- COPD mechanisms
- asthma
- asthma mechanisms
- COPD exacerbations
- cough/mechanisms/pharmacology
Remembering Freddy Hargreave
Respiratory Medicine lost a giant of airway disease research with the sudden death of Freddy Hargreave in June. Freddy devoted his career to the development of objective measures to assess airway disease. Notable achievements included developing a method to assess airway responsiveness, the first clear demonstration of a long term effect of allergen challenge on airway function and the development of induced sputum as a means to assess lower airway inflammation non-invasively. He trained a large number of current airway disease researchers. I count myself as being very fortunate to be one of their numbers. Paul O'Byrne and colleagues recount all that was special about Freddy (see page 1101). His approach was heavily influenced by clinical researchers at the Brompton and Hammersmith hospital in the late 1960s and was facilitated by a close and long-standing collaboration with his friend Jerry Dolovich at McMaster University. He focused on clinical issues of immediate importance to patients and his ideas came from taking a detailed history and careful analysis of the problems patients presented to him. This approach is …
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