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Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD
  1. Imran Haq1,2,
  2. Gillian E Lowrey1,
  3. Noor Kalsheker2,
  4. Simon R Johnson1
  1. 1Division of Therapeutics and Molecular Medicine, NIHR Respiratory Biomedical Research Unit, Queens Medical Centre, University of Nottingham, Nottingham, UK
  2. 2Division of Clinical Chemistry, Queen's Medical Centre, University of Nottingham, Nottingham, UK
  1. Correspondence to Simon Johnson, Division of Therapeutics and Molecular Medicine and NIHR Respiratory Biomedical Research Unit, Queens Medical Centre, University of Nottingham, D Floor, South Block, Queen's Medical Centre, Nottingham NG7 2UH, UK; simon.johnson{at}nottingham.ac.uk

Footnotes

  • NK and SRJ are joint senior authors.

  • Funding This study is funded by a Medical Research Council Capacity Building Studentship.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Nottingham Research Ethics Committee and all patients gave informed consent. Investigations into ECLIPSE resource were approved by the ECLIPSE steering committee. Informed consent and collection of the cohort was as described by Vestbo et al.11

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • NK and SRJ are joint senior authors.

  • Funding This study is funded by a Medical Research Council Capacity Building Studentship.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Nottingham Research Ethics Committee and all patients gave informed consent. Investigations into ECLIPSE resource were approved by the ECLIPSE steering committee. Informed consent and collection of the cohort was as described by Vestbo et al.11

  • Provenance and peer review Not commissioned; externally peer reviewed.

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