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Comparison of the utility of multiple breath inert gas washout parameters in cystic fibrosis
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  1. P D Robinson1,2,3,
  2. A Lindblad4,5,
  3. P M Gustafsson5,6
  1. 1Department of Respiratory Medicine, Childrens' Hospital at Westmead, Sydney, Australia
  2. 2The Children's Hospital at Westmead Clinical School, Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Australia
  3. 3Woolcock Institute of Medical Research, Sydney, Australia
  4. 4Department of Paediatrics, Queen Silvia's Children Hospital, Gothenburg, Sweden
  5. 5The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  6. 6Department of Paediatrics, Central Hospital, Skövde, Sweden
  1. Correspondence to Dr P D Robinson, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145 Australia; paulr3{at}chw.edu.au

https://doi.org/10.1136/thx.2009.121590

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    Ventilation inhomogeneity, measured using multiple breath washout (MBW), reflects small airway function and has emerged as a valuable tool in cystic fibrosis (CF). Improved sensitivity to detect early lung damage has been suggested from preschool children through to adults and confirmed in high-resolution CT (HRCT) studies.1 Longitudinal utility is now emerging.2 A large number of parameters reflecting overall ventilation inhomogeneity have been proposed, but consensus is lacking about the optimal parameter to report.

    The two …

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