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Longevity of alveolar macrophages allow sustained in vivo expression of the human α1-antitrypsin gene and amelioration of emphysema
  1. Toni Jordan
  1. Correspondence to Toni Jordan, Liverpool Heart & Chest Hospital, Liverpool, UK; Toni.Jordan{at}LHCH.nhs.UK

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This study describes the transduction of mouse pulmonary alveolar macrophages using an intratracheally instilled lentiviral vector. The transferred genes were expressed in vivo for the duration of the lifespan of the mouse. Labelling studies using bromodeoxyuridine (BrdU) revealed continued expression of the transgenes by alveolar macrophages present in the …

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