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Selective proteasome inhibitors may provide a novel therapeutic approach to Mycobacterium tuberculosis
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Proteasomes are large protein complexes that are structurally conserved across eukaryote cells including mycobacteria. They are needed to degrade unneeded or damaged proteins and, as such, have a vital role in cellular homeostasis. The cytotoxicity of proteasome inhibitors has been demonstrated by bortezomib (Velcade), which was the first therapeutic proteasome …