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  1. J G Mainz1,
  2. B Tümmler2
  1. 1Department of Pediatrics, CF Center, University Hospital of Jena, Germany
  2. 2Klinische Forschergruppe, Pediatric Pneumology, Medizinische Hochschule Hannover, Germany
  1. Correspondence to Dr J G Mainz, Cystic Fibrosis Center, Department of Pediatrics, University of Jena, Kochstrasse 2, D-07740 Jena, Germany; jochen.mainz{at}med.uni-jena.de

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We thank Dr Daniels for his comments on our paper and agree that “a cross-sectional study … provides no information as to the direction of transfer of bacteria between the upper and lower airways”. We therefore concluded in the abstract of our publication that “further longitudinal analyses and comparison with invasive methods …

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