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S56 EVIDENCE FOR ASSOCIATION BETWEEN SARCOIDOSIS AND PULMONARY EMBOLISM FROM 30-YEAR RECORD LINKAGE STUDY
1A. P. Nataraja, 2C. J. Wotton, 2M. J. Goldacre, 1L-P. Ho. 1Oxford Sarcoidosis Clinic, Oxford Centre for Respiratory Medicine, Oxford, UK; Radcliffe Hospitals NHS Trust and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK, 2Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Oxford, UK
Introduction Sarcoidosis is a multisystem disorder of unknown aetiology, characterised by the formation of non-caseating granuloma. A higher than expected incidence of pulmonary embolism (PE) was observed anecdotally in our Sarcoidosis Clinic over a 3-year period, raising the question of disease association.
Methods We carried out a retrospective cohort analysis using data from a well-established record linkage data set in Oxford (“ORLS”; years 1963–1998), and a more recent record linkage data set covering England (“England”; 1999–2005), to compare rate ratios (RRs) for pulmonary embolism and deep vein thrombosis (DVT) between people admitted to hospital for sarcoidosis and a reference cohort for all ages and those below 65 years. RRs of myocardial infarction, subarachnoid haemorrhage, abdominal aortic anerusym and cardiac failure were also analysed as controls. The reference cohorts comprised individuals with various minor medical and surgical conditions as main diagnoses (eg, squint, otitis media and nasal polyps). They were standardised by age, gender, year of first admission and district of residence. Rates of PE and control conditions were calculated based on person-years at risk, relative to that in the reference cohort. The confidence interval for the rate ratio and χ2 statistics for its significance were calculated.
Results We found a significantly increased RR for PE in patients with sarcoidosis, for patients both above and below 65 years of age, and in both data sets (RR 1.87, 95% CI 0.96–3.27 (ORLS); RR 2.72; 95% CI 1.52 to 4.50 (England) for all age patients). The …