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Risk of tuberculosis in close contacts of patients with multidrug resistant tuberculosis: a nationwide cohort
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  1. A Attamna1,
  2. D Chemtob2,
  3. S Attamna1,
  4. A Fraser3,
  5. E Rorman4,
  6. M Paul3,5,
  7. L Leibovici3,5
  1. 1
    Hasharon Regional Tuberculosis Clinic, Clalit Health Services, Hadera, Israel
  2. 2
    Department of Tuberculosis and AIDS, Ministry of Health, Jerusalem, Israel
  3. 3
    Department of Medicine E, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva, Israel
  4. 4
    National Public Health Laboratory, Ministry of Health, Tel-Aviv, Israel
  5. 5
    Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  1. Professor L Leibovici, Department of Medicine E, Beilinson Campus, Rabin Medical Centre, Petah-Tiqva 49100, Israel; leibovic{at}post.tau.ac.il

https://doi.org/10.1136/thx.2008.100974

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    Data on the efficacy of drugs for preventing multiple drug resistant tuberculosis (MDR-TB) in people at risk after close contact with patients is lacking. In a systematic review, we found only two small cohort studies that addressed this question.1 The aim of the present study was to describe the incidence of MDR-TB disease in people who were in close contact with patients with pulmonary MDR-TB, and to compare the incidence in people that were offered prophylaxis to those that were not (see online appendix).

    Patients with MDR-TB were identified by inspecting the records of patients that were referred to the nine designated TB centres in Israel; records of the national referral laboratory and the central registry held by the Ministry …

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