Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-κB dependent mechanism

D O’Toole; P Hassett; M Contreras; B D Higgins; S T W McKeown; D F McAuley; T O’Brien; J G Laffey

doi:10.1136/thx.2008.110304

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Acute lung injury

Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-κB dependent mechanism

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	Abstract	Full	Pdf
Jul 2009	136	0	23
Aug 2009	62	0	31
Sep 2009	31	0	17
Oct 2009	143	8	39
Nov 2009	125	34	84
Dec 2009	30	10	13
Jan 2010	40	12	14
Feb 2010	36	8	16
Mar 2010	17	23	15
Apr 2010	9	6	4
May 2010	16	10	9
Jun 2010	21	7	9
Jul 2010	21	4	13
Aug 2010	46	14	10
Sep 2010	49	6	5
Oct 2010	23	12	9
Nov 2010	13	8	5
Dec 2010	14	4	11
Jan 2011	14	11	7
Feb 2011	19	4	10
Mar 2011	17	2	7
Apr 2011	28	2	5
May 2011	22	3	2
Jun 2011	28	6	7
Jul 2011	25	4	6
Aug 2011	25	7	7
Sep 2011	23	4	5
Oct 2011	19	6	8
Nov 2011	15	4	7
Dec 2011	14	4	1
Jan 2012	19	4	4
Feb 2012	22	9	10
Mar 2012	23	3	6
Apr 2012	15	4	2
May 2012	28	2	8
Jun 2012	22	2	3
Jul 2012	28	7	8
Aug 2012	20	6	5
Sep 2012	36	0	1
Oct 2012	16	7	2
Nov 2012	22	5	7
Dec 2012	14	9	11
Jan 2013	21	14	22
Feb 2013	11	8	6
Mar 2013	16	7	20
Apr 2013	18	17	17
May 2013	14	6	17
Jun 2013	14	6	14
Jul 2013	7	8	13
Aug 2013	8	8	9
Sep 2013	11	9	19
Oct 2013	16	2	11
Nov 2013	11	5	8
Dec 2013	8	7	17
Jan 2014	12	7	12
Feb 2014	11	5	14
Mar 2014	21	11	8
Apr 2014	24	6	6
May 2014	32	8	11
Jun 2014	10	4	12
Jul 2014	24	15	11
Aug 2014	16	23	9
Sep 2014	30	27	8
Oct 2014	68	120	13
Nov 2014	40	56	5
Dec 2014	31	25	7
Jan 2015	15	20	11
Feb 2015	21	6	14
Mar 2015	13	24	11
Apr 2015	17	13	15
May 2015	24	17	15
Jun 2015	21	5	8
Jul 2015	14	8	10
Aug 2015	6	1	15
Sep 2015	15	12	16
Oct 2015	9	3	4
Nov 2015	10	3	10
Dec 2015	24	15	28
Jan 2016	27	4	13
Feb 2016	14	5	14
Mar 2016	4	13	19
Apr 2016	7	4	15
May 2016	17	10	27
Jun 2016	16	8	27
Jul 2016	15	11	36
Aug 2016	11	7	16
Sep 2016	16	5	17
Oct 2016	18	11	23
Nov 2016	29	13	22
Dec 2016	26	5	11
Jan 2017	17	7	7
Feb 2017	4	9	6
Mar 2017	5	22	12
Apr 2017	3	17	2
May 2017	3	14	9
Jun 2017	4	11	8
Jul 2017	11	11	7
Aug 2017	10	6	6
Sep 2017	23	19	6
Oct 2017	22	16	9
Nov 2017	12	8	2
Dec 2017	16	12	7
Jan 2018	21	13	5
Feb 2018	21	13	8
Mar 2018	24	18	11
Apr 2018	27	21	9
May 2018	13	14	9
Jun 2018	13	13	3
Jul 2018	24	20	5
Aug 2018	17	15	7
Sep 2018	8	6	8
Oct 2018	10	10	3
Nov 2018	33	33	9
Dec 2018	22	20	8
Jan 2019	18	15	5
Feb 2019	11	5	12
Mar 2019	16	14	11
Apr 2019	16	15	13
May 2019	18	17	21
Jun 2019	13	13	24
Jul 2019	10	9	17
Aug 2019	13	13	16
Sep 2019	9	9	13
Oct 2019	29	29	18
Nov 2019	27	19	21
Dec 2019	28	24	39
Jan 2020	36	32	22
Feb 2020	19	18	16
Mar 2020	19	17	24
Apr 2020	13	12	9
May 2020	11	9	13
Jun 2020	18	14	13
Jul 2020	16	14	4
Aug 2020	11	9	9
Sep 2020	32	30	8
Oct 2020	22	21	15
Nov 2020	27	27	8
Dec 2020	13	13	6
Jan 2021	13	11	5
Feb 2021	16	16	14
Mar 2021	13	10	9
Apr 2021	19	16	14
May 2021	16	16	14
Jun 2021	8	8	1
Jul 2021	10	10	16
Aug 2021	18	16	13
Sep 2021	12	10	4
Oct 2021	33	23	32
Nov 2021	30	24	30
Dec 2021	16	10	4
Jan 2022	38	34	19
Feb 2022	33	27	9
Mar 2022	51	53	19
Apr 2022	29	30	5
May 2022	54	46	42
Jun 2022	51	43	8
Jul 2022	41	32	9
Aug 2022	39	37	12
Sep 2022	45	41	20
Oct 2022	78	69	15
Nov 2022	52	48	6
Dec 2022	43	45	7
Jan 2023	54	53	12
Feb 2023	48	51	7
Mar 2023	37	34	5
Apr 2023	24	12	10
May 2023	19	13	18
Jun 2023	22	20	8
Jul 2023	16	14	10
Aug 2023	34	24	8
Sep 2023	35	32	12
Oct 2023	19	18	12
Nov 2023	28	19	13
Dec 2023	28	27	8
Jan 2024	25	24	17
Feb 2024	19	17	20
Mar 2024	23	22	128
Apr 2024	26	23	26
May 2024	31	15	11
Jun 2024	79	3	1
Jul 2024	76	3	4
Aug 2024	65	4	2
Total	4483	2757	2334

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