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The sst1 locus controls granuloma necrosis in tuberculosis
  1. M Almond
  1. Correspondence to Dr M Almond, ST1 Oncology, Royal Marsden Hospital, London, UK; mhalmond{at}

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There is broad variation in susceptibility to Mycobacterium tuberculosis (MTB), and mouse models play a key role in elucidating the underlying mechanisms. The authors tested the hypothesis that caseation within pulmonary lesions is a specific effect of the sst1 (supersusceptibility to tuberculosis 1) locus on chromosome 1.

Typical mouse lesions described in the literature lack central caseation. However, …

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