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Longitudinal changes in gastro-oesophageal reflux from 3 months to 6 months after lung transplantation
  1. A G N Robertson1,
  2. C Ward2,
  3. J P Pearson3,
  4. T Small2,
  5. J Lordan2,
  6. A J Fisher2,
  7. A J Bredenoord4,
  8. J Dark2,5,
  9. S M Griffin1,
  10. P A Corris2
  1. 1
    Northern Oesophago-Gastric Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK
  2. 2
    Applied Immunobiology and Transplantation Group, Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, UK
  3. 3
    Institute of Cellular and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, UK
  4. 4
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
  5. 5
    Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK
  1. Correspondence to Dr C Ward, Institute for Cellular Medicine, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK; chris.ward{at}ncl.ac.uk

https://doi.org/10.1136/thx.2009.117879

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    Gastro-oesophageal reflux (GOR) and microaspiration are implicated in the pathophysiology of asthma, chronic obstructive pulmonary disease, interstitial lung disease and chronic lung allograft dysfunction.1 2 Aspiration, which is often asymptomatic, has been identified as a treatable allograft injury that may affect mortality.1 2

    The potential for thoracic mechanical changes caused by advanced lung disease to predispose to reflux has been highlighted.2 Although aspiration could cause lung damage, alternatively reflux might represent a secondary event. Longitudinal data are lacking,2 so we have undertaken a prospective study of reflux in lung transplantation. This allowed investigations in patients where thoracic mechanical changes associated with advanced lung disease had improved. We hypothesised that reflux was prevalent and could develop at different times following transplantation in patients with good allograft function.

    Methods

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    Footnotes

    • Funding European Society for Organ Transplantation (AGNR), British Lung Foundation (AGNR), The Medical Research Council (PC, CW).

    • Competing interests None.

    • Ethics approval Patient consent and ethical approval obtained.

    • AR and CW made equal contributions.

    • Provenance and Peer review Not commissioned; not externally peer reviewed.

    • ▸ Table 1 is published online only at http://thorax.bmj.com/content/vol64/issue11