WISP-1, a novel target for treatment of pulmonary fibrosis
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Idiopathic pulmonary fibrosis (IPF) is characterised by formation of fibroblast foci and deposition of extracellular matrix (ECM) in the lung interstitium. This results in distorted lung architecture, impaired gas exchange and reduced respiratory function. Impaired crosstalk between alveolar type 11 (AT11) cells and subepithelial fibroblasts has previously been shown to contribute to ECM deposition in IPF. …