Article Text

Download PDFPDF
Lung alert
WISP-1, a novel target for treatment of pulmonary fibrosis
  1. A Singanayagam
  1. Correspondence to Dr A Singanayagam, FY1, Charing Cross Hospital, London, UK; anika.singa{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Idiopathic pulmonary fibrosis (IPF) is characterised by formation of fibroblast foci and deposition of extracellular matrix (ECM) in the lung interstitium. This results in distorted lung architecture, impaired gas exchange and reduced respiratory function. Impaired crosstalk between alveolar type 11 (AT11) cells and subepithelial fibroblasts has previously been shown to contribute to ECM deposition in IPF. …

View Full Text


  • Provenance and peer review Not commissioned; not externally peer reviewed.