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  1. H-J Aubin1,
  2. A Bobak2,
  3. J R Britton3,
  4. C Oncken4,
  5. C B Billing, Jr5,
  6. J Gong5,
  7. K E Williams5,
  8. K R Reeves5
  1. 1
    Hôpital Emile Roux, Assistance Publique-Hopitaux de Paris, Limeil-Brévannes, France; Centre d’Enseignement, de Recherche et de Traitement des Addictions, Hôpital Paul Brousse, Paris, France; Assistance Publique-Hôpitaux de Paris, Villejuif, France; INSERM, Paris, France
  2. 2
    Wandsworth Medical Centre, London, UK
  3. 3
    University of Nottingham, Nottingham, UK
  4. 4
    University of Connecticut Health Center, Farmington, Connecticut, USA
  5. 5
    Pfizer Global Research and Development, Groton, Connecticut, USA
  1. Dr H-J Aubin, Centre de Traitement des Addictions, Hôpital Emile Roux, F-94456 Limeil-Brévannes Cedex, France; henri-jean.aubin{at}erx.aphp.fr

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We acknowledge the proposition raised by Dr Rose that a comparison of nicotine replacement therapy (NRT) and varenicline using equal pre-cessation treatment regimens may result in different efficacy outcomes from those found in our trial. However, we would like to reiterate that our open-label comparison of varenicline with NRT was a pragmatic trial based on current treatment regimen recommendations by the manufacturers of the products and in accordance with current recommendations for transdermal NRT use in established health guidelines.1 2

Dr Rose suggests that the imbalance in pre-cessation treatment between products in our trial reflects a flaw in the design of our study. The objective of this study was to compare …

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